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br Discussion br Phthalate esters have been
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4. Discussion Phthalate esters have been defined as environmental endocrine disruptors, which possess the ability to disturb sexual maturation, pregnancy loss, female reproductive tract and mammary gland devel-opment, male testicular development and sperm production (Piche et al., 2012; Kay et
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br Fundings br This work was supported
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Fundings This work was supported by the China Postdoctoral Science Foundation (grant numbers 2018M643676) and Shaanxi Province Postdoctoral Science Foundation. Conflicts of interest The authors declared that there is no conflict of interest. Acknowledgements JS Z and YY H conceived
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br Montero A Fossella F
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[3] Montero A, Fossella F, Hortobagyi G, and Valero V (2005). Docetaxel for treatment of solid tumours: PX-478 systematic review of clinical data. Lancet Oncol 6, 229–239. [4] Bolis G, Scarfone G, Raspagliesi F, Mangili G, Danese S, Scollo P, Lo Russo D, Villa A, Aimone PD, and Scambia G (2010).
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Archives of Oral Biology br Fig
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Archives of Oral Biology 97 (2019) 231–237 Fig. 1. Experimental protocols timeline. A. Heat stimulation: on day 0, baseline to facial heat stimulation was collected followed by the inoculation of tumor Cy5.5 NHS ester into animal’s right vibrissal pad. On day 6 after inoculation, facial heat s
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br Ganesh S Shui X Craig KP et al RNAi
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128. Ganesh S, Shui X, Craig KP, et al. RNAi-Mediated beta-Catenin Inhibition Promotes T Cell Infiltration and Antitumor Activity in Combination with Immune Checkpoint Blockade. Molecular therapy : the journal of the American Society of Gene Therapy. Nov 7 2018;26(11):2567-2579. 130. Jacobson M
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br Results and discussion br The bacterial culture of Bacillus
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3. Results and discussion The bacterial culture of Bacillus cereus (ATCC 14579) was utilized Fig. 2. FTIR Spectra of filtrate, AgNPs and cAgNPs synthesized from Bacillus cereus where (A) filtrate (B) AgNPs, (C) cAgNPs. Fig. 3. UV –spectrophotometer analysis showing peak at 412 nm and FTIR
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br From a protein array screen we
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From a protein array screen, we observed that the compounds interfered with the protein expression levels of CapG, ErbB2, FGF-basic, FOXC2, HIF-1a, Tenascin C and CD31/PECAM-1 all of which are involved in several aspects of tumor malignancy and their in-dividual or collective overexpression correl
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br Statistical analysis br Data are presented
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4.11. Statistical analysis Data are presented as mean ± standard deviation. SPSS 16.0 (SPSS, Chicago, IL) software was applied to perform statistical analysis. Competing interests The authors declare that they have no competing interests. Acknowledgements This research was supported
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br Assessment of the IRE and PERK eIF branches
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Assessment of the IRE1α and PERK/eIF2α branches of the UPR AGS Mitomycin C were plated at 1.5 × 104 cells/well and incubated with the benzoquinones under study for 8 h in the presence or absence of 4μ8C (5 µm) or salubrinal (40 µm), IRE1α and PERK reference in-hibitors respectively. The effects
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br Autophagy removes oncogenic proteins and maintains genomic stability br
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3.1.1. Autophagy removes oncogenic proteins and maintains genomic stability p53 is activated in response to a variety of stress conditions, in-cluding DNA damage, oxidative stress, replicative stress, genomic in-stability etc. (Meek, 2015). In cancer cells, the proteasomal degradation of the mu
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Statistical analysis br ACCEPTED MANUSCRIPT br Continuous variables were described
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Statistical analysis ACCEPTED MANUSCRIPT Continuous variables were described as the mean ± standard deviation (SD) for normally distributed variables or the median for variables with a skewed distribution. Categorical variables were described as percentages. Comparisons among groups were condu
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br There are a few limitations to this study
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There are a few limitations to this study that should be mentioned. First, the prognostic information of patients with breast cancer with KMT2C mutations is absent for the Chinese cohort. Second, we identi-fied several significant differences between the Chinese, TCGA, and METABRIC cohorts, such a
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br CTU represents a new lead compound with potential
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CTU represents a new lead compound with potential anti-cancer activity, and a well-defined structure-activity relationship (SAR) is now required for its optimization and development. From our initial series of analogues it appeared that substitution of the ω-terminal aryl system with strong electr
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br Conclusions br In this study
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5. Conclusions In this study, we constructed the human prostate cancer PC-3-luc Mitoquinol with a stable expression of the luciferase gene and it was have the same biological characteristics as PC-3 cells, so PC-3-luc cells can replace PC-3 cells for in vivo and in vitro experiments. Ad-VT has
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br The caspases cascade is groups of proteinases that
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The caspases cascade is groups of proteinases that have central roles in the activation of apoptosis. Activation of specific caspase determines the cell death pathways, for instance, activation of caspase-8 indicates the involvement of the extrinsic apoptosis pathway, while activation of caspase-9