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  • br Conclusions br In this nationwide study we found

    2020-07-29


    Conclusions
    In this Oxaliplatin nationwide study, we found that the post-operative AL rate in patients operated with AR for rectal cancer after being previously treated with RT for prostate cancer was much lower than that reported previously. The leaks seldom required a re-laparotomy and there was no post-operative mortality. Most of the previously irradiated patients were resected without an anas-tomosis, and only a selected group of patients had an AR, which indicates that surgeons on a national level were aware of the high risk of anastomotic complications in a previously irradiated pelvis.
    Conflicts of interest
    The authors declare that there are no potential conflicts of interest.
    Role of the funding source
    The funding source were not involved in this study.
    Acknowledgements
    This study was supported by a research grant from the County of V€astmanland, Sweden (Grant number: LTV-747101).
    Appendix
    Table A1
    Logistic regression of risk factors for intra-abdominal infection or anastomotic leakage in patients who underwent anterior resection between 2000 and 2016.
    At risk Events Univariable
    Multivariable OR 95% CI
    OR
    Treatment group
    OR, odds ratio; CI, confidence interval; ASA, American Society of Anesthesiologists.
    Note: Only registry data. * Had not received RT for PC but have received anterior resection with pre-operative RT or CRT.
    Table A2
    Multivariable logistic regression analysis of risk factors for anastomotic leakage in patients who underwent anterior resection and had previously received radio-therapy for prostate cancer between 2000 and 2016.
    Multivariable
    At risk Events OR 95% CI
    OR, odds ratio; CI, confidence interval; ASA, American Society of Anesthesiologists.
    Note: Registry and chart-review data.
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